©2018-2019 by Ciliary Motility, Mechanics, and Mechanobiology Lab

Biology is replete with examples of dynamic self-assembly, organization and movement that span subcellular, cellular, and multicellular length scales. In these examples, chemical, thermal and mechanical cues guide growth, organization and size and then eventually form and function. Most of the focus has been rightly until now on elucidating the biological and biochemical underpinnings of biophysical phenomena. It is becoming increasingly clear that elasticity and fluid flow constitute an important and integral part of how single cells, organelles, and multi-cellular organisms function, grow and interact. Dramatic advances in microscale engineering and microscopy have provided us with new, powerful tools to explore these interactions at varied and length and time scales: thus, opening new avenues to understand these biological “systems” and engineer synthetic “life-like” mimics.

The current focus of our research is to combine  experimental observations with minimal analytical models, phenomenological mesoscale theories and agent-based discrete computations to understand the origin of function in living matter at scales ranging from the molecular to multicellular. Specific research projects are listed below.

       BIOMECHANICS & BIOLOGICAL MECHANICS

         Active elastohydrodynamics: Mechanics, Memory, Collective interactions, Motility and Adhesion

Biorheology and biomechanics of Candida albicans Biofilms on Mucus

       MECHANOBIOLOGY AND SIGNALING IN CILIA

How cilia beat: Phototaxis and motility in Chlamydomonas reinhardtii 

Systems control and steering mechanics in ciliated organisms

Light-matter interactions and motility in Chlamydomonas

       

STATISTICAL PHYSICS OF ACTIVE SYSTEMS

Interfacial mechanics and thermodynamics in living multi-phase systems

Mechanical memory, collectivity and pattern formation in filament motor aggregates

Statistical mechanics of constrained active semi-flexible filaments in crowded environments

Multicellular motility and synchronization

       MATHEMATICAL BIOLOGY AND MODELING

        Multi-scale models for active multi-species fluids

        Microorganism Locomotion in Complex Fluids

 

        Fitness, motility and co-evolution in swarming bacterial systems

Application of singular perturbation theory to systems in biology